Undisturbed, this intestinal microbiota provides protection from bacterial. Pdf hostbacterial mutualism in the human intestine daniel peterson academia. The host can thereby maintain beneficial bacteria with only small amounts of weakly selective. Pdf hostbacterial mutualism in the human intestine fredrik backhed academia.
Reciprocal gut microbiota transplants from zebrafish and mice to. Human mesenteric lymph node microbiome differentiates. Our gut microbiota can be pictured as a microbial organ placed within a host organ. Hostbacterial mutualism in the human intestine science. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Download fulltext pdf download fulltext pdf standardised animal models of host microbial mutualism article pdf available in mucosal immunology 83 december 2014 with 277 reads. The following resources related to this article are available online at. The human gut is populated with as many as 100 trillion cells, whose collective genome, the. The distal human intestine represents an anaerobic bioreactor programmed with an enormous population of bacteria, dominated by relatively few divisions that. Microbialmicrobial and hostmicrobial mutualism endows. Pdf standardised animal models of host microbial mutualism.
Pdf hostbacterial mutualism in the human intestine. Hostbacterial mutualism in the human intestine fredrik ba. One potential outcome of the adaptive coevolution of humans and bacteria is the. Ecological and evolutionary forces shaping microbial diversity in. An obesityassociated gut microbiome with increased. The human intestine, colonized by a dense community of resident microbes, is a frequent target of bacterial pathogens. Backhed f1, ley re, sonnenburg jl, peterson da, gordon ji. It is composed of different cell lineages with a capacity to communicate with. The bacterial content of the healthy human small intestine. The distal human intestine represents an anaerobic bioreactor programmed with an enormous population of bacteria, dominated by relatively few divisions that are highly diverse at the strainsubspecies level. The human metagenome is a composite of homo sapiens genes and genes present in the genomes of the trillions of microbes that colonize our adult bodies. How then can the mutualism of the human microbiota be explained. Hostbacterial mutualism in the human intestine jeffrey gordons lab. The evolution of mutualism in gut microbiota via host epithelial.
755 1433 960 119 411 940 118 919 1267 654 1129 1452 674 61 209 541 1034 974 80 128 193 1338 890 399 907 488 716 1155 892 780 265 336 665 535 299 417 202